Crystal Structures of Bence-Jones proteins




Based on sequence alignment, the group of Prof. H-J. Fritz (Molekulare Genetik, Universität Göttingen), has been studying the stabilisation of immunoglobulin domains through designed aminoacid exchange.




In the structure, we can see the causes of the stabilisation of the fold in REI mutants.







Now, could a stabilised REI protein maintain its fold and be stable without the only disulphide bridge?




Some references.

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