Crystal Structures of Bence-Jones proteins
Based on sequence alignment, the group of Prof. H-J. Fritz
(Molekulare Genetik, Universität Göttingen), has been studying the stabilisation
of immunoglobulin domains through designed aminoacid exchange.
In the structure, we can see the causes of the stabilisation of the
fold in REI mutants.
Now, could a stabilised REI protein maintain its fold and be stable
the only disulphide bridge?