The bacterial arylsulfatase from Pseudomonas aeruginosa
(PAS) shows the same overall fold as the human arylsulfatases.
The active site is conserved among arylsulfatases. This allows a consensus mechanismus for sulfate ester cleavage to be derived for the arylsulfatase family.
Sulfate ester cleavage mechanism in the sulfatase family.
This work was done in collaboration with the groups
of Dr. Kertesz (Biological Sciences, Manchester) and Prof. von Figura,
Dr. Schmidt and PD. Dr. Dierks (Biochemie II, Göttingen).